Desktop Manager 18.104.22.168 made a pretty splash when the BlackBerry Tour was released. I got quite a few emails these past few days that RIM has been pushing out Desktop Manager 22.214.171.124 as an automatic update. Until now I just assumed it was a bug fix but did not know what it fixed exactly so I did not mention it.
Tom and a few other readers sent in tips pointing to the fact that this version fixes some of the database backup errors causing problems in 5.0. For example when doing a backup, instead of failing when there is an error, it will now tell you what database failed and offer to continue and complete the backup. Now that is worth mentioning!